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1

Molecular Mechanisms of Skin Aging and Age-Related Diseases || Changes of Skin Barrier with Aging

Year:

2016

Language:

english

File:

PDF, 857 KB

english, 2016

2

Enhancing Structural Support of the Dermal Microenvironment Activates Fibroblasts, Endothelial Cells, and Keratinocytes in Aged Human Skin In Vivo

Quan, Taihao, Wang, Frank, Shao, Yuan, Rittié, Laure, Xia, Wei, Orringer, Jeffrey S, Voorhees, John J, Fisher, Gary J

Journal:

The Journal of Investigative Dermatology

Year:

2013

Language:

english

File:

PDF, 2.98 MB

english, 2013

3

Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts

He, Tianyuan, Quan, Taihao, Shao, Yuan, Voorhees, John J., Fisher, Gary J.

Journal:

Year:

2014

Language:

english

File:

PDF, 999 KB

english, 2014

4

Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review

Quan, Taihao, Fisher, Gary J.

Journal:

Year:

2015

Language:

english

File:

PDF, 115 KB

english, 2015

5

Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector

States, J.Christopher, Quan, TaiHao, Hines, Ronald N., Novak, Raymond F., Runge-Morris, Melissa

Journal:

Year:

1993

Language:

english

File:

PDF, 6.46 MB

english, 1993

6

Reduction of fibroblast size/mechanical force down-regulates TGF-β type II receptor: implications for human skin aging

Fisher, Gary J., Shao, Yuan, He, Tianyuan, Qin, Zhaoping, Perry, Daniel, Voorhees, John J., Quan, Taihao

Journal:

Year:

2016

Language:

english

File:

PDF, 1.27 MB

english, 2016

7

Preferential DNA damage in the p53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells

TaiHao Quan, J. Christopher States

Journal:

Molecular Carcinogenesis

Year:

1996

Language:

english

File:

PDF, 1.34 MB

english, 1996

8

Differential mutagenicity and cytotoxicity of (±)-benzo[a]pyrene-trans-7,8-dihydrodiol and (±)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9, 10-epoxide in genetically engineered human fibroblasts

Taihao Quan, John J. Reiners, Jr. Sandra J. Culp, Patricia Richter, J. Christopher States

Journal:

Molecular Carcinogenesis

Year:

1995

Language:

english

File:

PDF, 1.04 MB

english, 1995

9

Connective Tissue Growth Factor: Expression in Human Skin In Vivo and Inhibition by Ultraviolet Irradiation

Quan, Taihao, He, Tianyuan, Kang, Sewon, Voorhees, John J., Fisher, Gary J.

Journal:

The Journal of Investigative Dermatology

Year:

2002

Language:

english

File:

PDF, 211 KB

english, 2002

10

Ultraviolet Irradiation Alters Transforming Growth Factor beta/Smad Pathway in Human Skin In Vivo

Quan, TaiHao, He, TianYuan, Kang, Sewon, Voorhees, John J., Fisher, Gary J.

Journal:

The Journal of Investigative Dermatology

Year:

2002

Language:

english

File:

PDF, 367 KB

english, 2002

11

Expression of CCN family of genes in human skinin vivoand alterations by solar-simulated ultraviolet irradiation

Taihao Quan, Sharon Shin, Zhaoping Qin, Gary J. Fisher

Journal:

Journal of Cell Communication and Signaling

Year:

2009

Language:

english

File:

PDF, 120 KB

english, 2009

12

CCN1 contributes to skin connective tissue aging by inducing age-associated secretory phenotype in human skin dermal fibroblasts

Taihao Quan, Zhaoping Qin, Patrick Robichaud, John J. Voorhees, Gary J. Fisher

Journal:

Journal of Cell Communication and Signaling

Year:

2011

Language:

english

File:

PDF, 470 KB

english, 2011

13

Retinoids suppress cysteine-rich protein 61 (CCN1), a negative regulator of collagen homeostasis, in skin equivalent cultures and aged human skin in vivo

Taihao Quan, Zhaoping Qin, Yuan Shao, Yiru Xu, John J. Voorhees, Gary J. Fisher

Journal:

Experimental Dermatology

Year:

2011

Language:

english

File:

PDF, 435 KB

english, 2011

14

Reduced Expression of Connective Tissue Growth Factor (CTGF/CCN2) Mediates Collagen Loss in Chronologically Aged Human Skin

Quan, TaiHao, Shao, Yuan, He, Tianyuan, Voorhees, John J, Fisher, Gary J

Journal:

The Journal of Investigative Dermatology

Year:

2009

Language:

english

File:

PDF, 1.55 MB

english, 2009

15

Cysteine-rich protein 61 (CCN1) mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts

Taihao Quan, Zhaoping Qin, John J. Voorhees, Gary J. Fisher

Journal:

Journal of Cellular Biochemistry

Year:

2012

Language:

english

File:

PDF, 499 KB

english, 2012

16

Matrix-Degrading Metalloproteinases in Photoaging

Quan, Taihao, Qin, Zhaoping, Xia, Wei, Shao, Yuan, Voorhees, John J, Fisher, Gary J

Journal:

JID Symposium Proceedings

Year:

2009

Language:

english

File:

PDF, 1.63 MB

english, 2009

17

Solar Ultraviolet Irradiation Reduces Collagen in Photoaged Human Skin by Blocking Transforming Growth Factor-β Type II Receptor/Smad Signaling

Taihao Quan, Tianyuan He, Sewon Kang, John J. Voorhees, Gary J. Fisher

Journal:

The American Journal of Pathology

Year:

2004

Language:

english

File:

PDF, 705 KB

english, 2004

18

Elevated Cysteine-Rich 61 Mediates Aberrant Collagen Homeostasis in Chronologically Aged and Photoaged Human Skin

TaiHao Quan, TianYuan He, Yuan Shao, Lin Lin, Sewon Kang, John J. Voorhees, Gary J. Fisher

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 551 KB

english, 2006

19

Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin

Gary J. Fisher, Taihao Quan, Trupta Purohit, Yuan Shao, Moon Kyun Cho, Tianyuan He, James Varani, Sewon Kang, John J. Voorhees

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 1.54 MB

english, 2009

20

Elevated Matrix Metalloproteinases and Collagen Fragmentation in Photodamaged Human Skin: Impact of Altered Extracellular Matrix Microenvironment on Dermal Fibroblast Function

Quan, Taihao, Little, Emily, Quan, Hehui, Qin, Zhaoping, Voorhees, John J, Fisher, Gary J

Journal:

The Journal of Investigative Dermatology

Year:

2013

Language:

english

File:

PDF, 481 KB

english, 2013

21

Elevated cysteine-rich protein 61 (CCN1) promotes skin aging via upregulation of IL-1β in chronically sun-exposed human skin

Zhaoping Qin, Toru Okubo, John J. Voorhees, Gary J. Fisher, Taihao Quan

Journal:

Year:

2014

Language:

english

File:

PDF, 641 KB

english, 2014

22

Elevated YAP and Its Downstream Targets CCN1 and CCN2 in Basal Cell Carcinoma

Quan, Taihao, Xu, Yiru, Qin, Zhaoping, Robichaud, Patrick, Betcher, Stephanie, Calderone, Ken, He, Tianyuan, Johnson, Timothy M., Voorhees, John J., Fisher, Gary J.

Journal:

The American Journal of Pathology

Year:

2014

Language:

english

File:

PDF, 1.57 MB

english, 2014

23

Ultraviolet irradiation represses TGF-β type II receptor transcription through a 38-bp sequence in the proximal promoter in human skin fibroblasts

He, Tianyuan, Quan, Taihao, Fisher, Gary J.

Journal:

Experimental Dermatology

Year:

2014

Language:

english

File:

PDF, 490 KB

english, 2014

24

A mouse model of skin aging: Fragmentation of dermal collagen fibrils and reduced fibroblast spreading due to expression of human matrix metalloproteinase-1

Xia, Wei, Quan, Taihao, Hammerberg, Craig, Voorhees, John J., Fisher, Gary J.

Journal:

Journal of Dermatological Science

Year:

2015

Language:

english

File:

PDF, 1.31 MB

english, 2015

25

Age-associated reduction of cellular spreading/mechanical force up-regulates matrix metalloproteinase-1 expression and collagen fibril fragmentation via c-Jun/AP-1 in human dermal fibroblasts

Qin, Zhaoping, Voorhees, John J., Fisher, Gary J., Quan, Taihao

Journal:

Year:

2014

Language:

english

File:

PDF, 811 KB

english, 2014

26

Expression of catalytically active matrix metalloproteinase-1 in dermal fibroblasts induces collagen fragmentation and functional alterations that resemble aged human skin

Xia, Wei, Hammerberg, Craig, Li, Yong, He, Tianyuan, Quan, Taihao, Voorhees, John J., Fisher, Gary J.

Journal:

Year:

2013

Language:

english

File:

PDF, 586 KB

english, 2013

27

Effect of Increased Pigmentation on the Antifibrotic Response of Human Skin to UV-A1 Phototherapy

Wang, Frank, Garza, Luis A., Cho, Soyun, Kafi, Reza, Hammerberg, Craig, Quan, Taihao, Hamilton, Ted, Mayes, Maureen, Ratanatharathorn, Voravit, Voorhees, John J., Fisher, Gary J., Kang, Sewon

Journal:

Archives of Dermatology

Year:

2008

Language:

english

File:

PDF, 216 KB

english, 2008

28

Cytotoxicity and genotoxicity of (±)-benzo[ a ]pyrene- trans -7,8-dihydrodiol in CYP1A1-expressing human fibroblasts quantitatively correlate with CYP1A1 expression level

Quan, TaiHao, Reiners, John J., Bell, Alonzo O., Hong, Nancy, States, J.Christopher

Journal:

Year:

1994

Language:

english

File:

PDF, 765 KB

english, 1994

29

Ultraviolet Irradiation Induces CYR61/CCN1, a Mediator of Collagen Homeostasis, through Activation of Transcription Factor AP-1 in Human Skin Fibroblasts

Quan, Taihao, Qin, Zhaoping, Xu, Yiru, He, Tianyuan, Kang, Sewon, Voorhees, John J, Fisher, Gary J

Journal:

The Journal of Investigative Dermatology

Year:

2010

Language:

english

File:

PDF, 934 KB

english, 2010

30

CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?

Quan, Taihao, Johnston, Andrew, Gudjonsson, Johann E, Fisher, Gary J

Journal:

The Journal of Investigative Dermatology

Year:

2015

Language:

english

File:

PDF, 204 KB

english, 2015

31

Age-associated reduction of cell spreading induces mitochondrial DNA common deletion by oxidative stress in human skin dermal fibroblasts: implication for human skin connective tissue aging

Quan, Chunji, Cho, Moon Kyun, Perry, Daniel, Quan, Taihao

Journal:

Journal of Biomedical Science

Year:

2015

Language:

english

File:

PDF, 3.63 MB

english, 2015

32

Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging

Purohit, Trupta, He, Tianyuan, Qin, Zhaoping, Li, Ting, Fisher, Gary J., Yan, Yan, Voorhees, John J., Quan, Taihao

Journal:

Journal of Dermatological Science

Year:

2016

Language:

english

File:

PDF, 829 KB

english, 2016

33

Molecular Mechanisms of Skin Aging and Age-Related Diseases || Aging Skin: A Window to the Body

Year:

2016

Language:

english

File:

PDF, 513 KB

english, 2016

34

Cell-size-dependent upregulation of HGF expression in dermal fibroblasts: impact on human skin connective tissue aging

Qin, Zhaoping, Worthen, Christal A., Quan, Taihao

Journal:

Journal of Dermatological Science

Year:

2017

Language:

english

File:

PDF, 632 KB

english, 2017

35

Ezrin regulates skin fibroblast size/mechanical properties and YAP-dependent proliferation

Quan, Chunji, Yan, Yan, Qin, Zhaoping, Lin, Zhenhua, Quan, Taihao

Journal:

Journal of Cell Communication and Signaling

Year:

2017

Language:

english

File:

PDF, 2.42 MB

english, 2017

36

Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging

Cole, Megan A., Quan, Taihao, Voorhees, John J., Fisher, Gary J.

Journal:

Journal of Cell Communication and Signaling

Year:

2018

Language:

english

File:

PDF, 1.26 MB

english, 2018

37

YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts

Qin, Zhaoping, Xia, Wei, Fisher, Gary J., Voorhees, John J., Quan, Taihao

Journal:

Cell Communication and Signaling

Year:

2018

Language:

english

File:

PDF, 1.58 MB

english, 2018

38

Actin cytoskeleton assembly regulates collagen production via TGF-β type II receptor in human skin fibroblasts

Qin, Zhaoping, Fisher, Gary J., Voorhees, John J., Quan, Taihao

Journal:

Journal of Cellular and Molecular Medicine

Year:

2018

Language:

english

File:

PDF, 2.09 MB

english, 2018

39

Oxidant Exposure Induces Cysteine-Rich Protein 61 (CCN1) via c-Jun/AP-1 to Reduce Collagen Expression in Human Dermal Fibroblasts

Qin, Zhaoping, Robichaud, Patrick, He, Tianyuan, Fisher, Gary J., Voorhees, John J., Quan, Taihao, Zhou, Zhongjun

Journal:

Year:

2014

Language:

english

File:

PDF, 1.86 MB

english, 2014

40

Physical properties of the photodamaged human skin dermis: rougher collagen surface and stiffer/harder mechanical properties

Shao, Yuan, Qin, Zhaoping, Alexander Wilks, James, Balimunkwe, Rebecca Mutesi, Fisher, Gary J, Voorhees, John J., Quan, Taihao

Journal:

Experimental Dermatology

Year:

2018

Language:

english

File:

PDF, 1009 KB

english, 2018

41

Oxidative Stress and Human Skin Connective Tissue Aging

Tu, Yidong, Quan, Taihao

Journal:

Year:

2016

Language:

english

File:

PDF, 1.79 MB

english, 2016

42

Alterations in extracellular matrix composition during aging and photoaging of the skin

McCabe, Maxwell C., Hill, Ryan C., Calderone, Kenneth, Cui, Yilei, Yan, Yan, Quan, Taihao, Fisher, Gary J., Hansen, Kirk C.

Journal:

Matrix Biology Plus

Year:

2020

File:

PDF, 3.35 MB

2020

43

Dermal Fibroblast CCN1 Expression in Mice Recapitulates Human Skin Dermal Aging

Quan, Taihao, Xiang, Yaping, Liu, Yingchun, Qin, Zhaoping, Yang, Yan, Bou-Gharios, George, Voorhees, John J., Dlugosz, Andrzej A., Fisher, Gary J.

Journal:

The Journal of Investigative Dermatology

Year:

2020

File:

PDF, 4.32 MB

2020